Fairbrother KJ, Heasman PA: Anticalculus agents. J Clin Periodontol ; the research associated with the development of anticalculus agents and to evalu-. Request PDF on ResearchGate | Anticalculus agents | Most dentifrices and some mouthrinses now contain 1 or more active anticalculus agents to achieve. With the help of antiplaque and anticalculus agents. Chemical plaque control – Rationale. Gingivitis & periodontitis are highly prevalent diseases and.

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The liquid mouthwash is then agitated for from about 10 seconds to about 10 min.

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Colloidal magnesium aluminum silicate or finely divided silica can be used as part of the thickening agent to further improve texture. Preferred precipitated silica materials include those marketed by the J. The applicating device may be further used to effect anticalcilus even distribution of the oral composition to the tooth surface, for example by brushing.

Coloring agents may be added to anticaclulus of this invention to improve appearance. As used herein, percentages listed are weight percentage of composition unless otherwise specified. In certain embodiments, zinc oxide may be used as zinc ion source of the oral care composition.

The preservatives prevent microbial growth in the compositions.

Preferred zincxitrate ratios are from about 1: Typically, the growth will be built up over a period of four to five days and will involve cycling the rods between product treatment, saliva, and nutrient broth. We are particularly adept in designing bespoke in vitro models to cater for your specific requirements.

Within the mouth, the gums, lips, oral mucosa cheekpalate, tongue and teeth provide surfaces for the colonization and accumulation of bacteria. The applicating device is then contacted with the oral cavity surfaces in a manner such that the oral composition is contacted with tissue of the oral cavity, especially the teeth and gums.


Suitable sources of citrate ions include citric acid; alkali metal salts of citric acid, especially sodium citrate and potassium citrate; pharmaceutically acceptable hydrated and dehydrated salts of any of the above; and mixtures of any of the above. Calculus is the most common calcified deposit in the oral cavity that forms on teeth with a covering layer of viable plaque, and remains in close juxtaposition to the gingival and supporting tissues and generates concern in periodontal disease.

It has been found that phosphate-containing anticalculus agents such as tetrasodium pyrophosphate and sodium tripolyphosphate appear to inhibit uptake of antibacterial biphenoyl compounds. Magnolol and honokiol are non-ionic hydroxybiphenyl compounds, the structures of which are represented as follows: The compositions must be at a pH which is safe for contact with the tissues of the.

An Overview on anticalculus agents – A review.

For example, while dentifrice containing no zinc salt Formulas 9 provided the delivery of Other optional ingredients include a safe and effective amount of a fluoride ion source, which typically is in the form of a water-soluble fluoride compound. Such compositions are described hereinabove. Surfactants may also be used as solubilizing agents to help retain sparingly soluble components, e. Such compositions comprise certain zinc salts and certain molar ratio amounts of citrate and pyro relative to zinc in a pharmaceutically- acceptable carrier.

In fact, if anything, the addition of a zinc ion source such as zinc oxide to compositions according to the present invention improves the delivery of the biphenol compound. These reactions lead to the destruction of the supporting structure, continued infection, and potentially the subsequent loss of teeth.

When the oral composition is a toothpaste, preferably from about 0. The composition of Claim 1 in the form of a dentifrice wherein the pharmaceutically acceptable topical oral carrier comprises a dental abrasive.


Anticalculus agents for the treatment, control, and prevention of periodontal disease.

Certification Formally confirming that your products and services meet all trusted external and internal standards. In one embodiment, it is present in the oral care composition in a concentration of about 0. Dentifrice with improved cleansing and polishing action – contg. Thus, there is a need for a highly effective antibacterial, antiplaque and anticalculus oral care composition to prevent or diminish oral care diseases.

Such topical oral carrier, when combined with Actives of this invention, results in a composition which is administered topically to the oral cavity. Dental calculus, or tartar, is a hard mineralized solid formed on the teeth when anticalculux of calcium phosphate are deposited in the pellicle and extracellular matrix of the dental plaque and become crystalline hydroxyapatite, sufficiently closely packed together for the aggregates to become resistant to deformation.

It should be noted that any plant from the Magnoliaceae family is suitable for the present invention and may be used in alternative anticakculus. Date of ref document: By making the compositions phosphate-free this inhibition is not observed.

Anticalculus agents.

Inspection Validating the specifications, value and safety of your raw materials, products and assets. The compositions of this invention can be made using methods which are anticalcuous used to produce oral care products.

Saccharin salts are preferred. Nutrients can also be present in the oral agehts of this invention, on condition that they are compatible with the Actives.

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