Sandostatin Injection is available as: sterile 1-mL ampuls in 3 strengths, containing 50, mcg octreotide (as acetate), and sterile 5-mL multi-dose vials in 2. Sep 3, Octreotide Acetate (Sandostatin ®) – Intravenous (IV) Dilution. Octreotide (Sandostatin) is the longer acting synthetic analogue of the naturally In patients with cancer and inoperable bowel obstruction octreotide rapidly.
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To email a medicine you must sign up and log in. In patients with inoperable benign or malignant tumours, glycaemic control may be octreotidr without concomitant sustained reduction in circulating insulin levels. Cholecystitis, biliary sludge, hyperbilirubinaemia.
Company contact details Hospira UK Ltd. Dose adjustments of insulin and antidiabetic medicinal products may be required when Octreotide is administered concomitantly see section 4.
Oesophageal varices Since, following bleeding episodes from oesophageal varices, there is an increased risk for the development of insulin-dependent diabetes or for changes in insulin requirement in patients with pre-existing diabetes, an appropriate monitoring of blood glucose levels is mandatory.
Renal or hepatic impairment. No hyperplastic or neoplastic lesions occurred at the s. ocrreotide
Sandostatin 50 microgram/1 ml, solution for injection/infusion
Instructions for use and handling Ampoule is intended for single use only; it should be opened just prior to administration and any unused portion discarded. Step 7 After the saturation period, ensure plunger dosiw pushed all the way down in the syringe Keep plunger pressed and octrfotide vial moderately in a horizontal direction for a minimum of 30 seconds so the powder is completely suspended uniform milky suspension.
From a microbiological point of view, the diluted solution should preferably be used immediately. In some patients, computed tomography scanning suggests a slowing or arrest of progression of the tumour, or even tumour shrinkage, particularly of hepatic metastases. In emergency situations may be given by IV bolus undiluted over 3 to 5 minutes.
Limited published data indicate that somatostatin analogues might decrease the metabolic clearance of compounds odtreotide to be metabolised by cytochrome P enzymes, which may be due to the suppression of growth hormone.
As GH-secreting pituitary tumours may sometimes expand, causing serious complications e. In most cases, administration of Sandostatin results in alleviation of the severe secretory diarrhoea typical of the condition, with consequent improvement in quality of life. The treatment effects of Sandostatin were prospectively observed in 21 patients and pooled with series of 37 published cases.
Sandostatin contains less than 1 mmol 23 mg sodium per dose, i. A maximum dose of 1.
SANDOSTATIN Dosage & Rx Info | Uses, Side Effects – MPR
Treatment of TSH-secreting pituitary adenomas: It is unknown whether octreotide is excreted in human breast milk. There is a limited amount of otreotide less than pregnancy outcomes from dsis use of octreotide in pregnant women, and in approximately one third of the cases the pregnancy outcomes are unknown. This information occtreotide intended for use by health professionals.
Elevated transaminase levels Skin and subcutaneous tissue disorders Common: Complications following pancreatic surgery For patients undergoing pancreatic surgery, the peri- and post-operative administration of Octreotide reduces the incidence of typical post-operative complications e.
Administration of Sandostatin may result in improvement of symptoms, particularly of flushing and diarrhoea. Or click OK to continue. Octreotide is also indicated for acromegalic patients unfit or unwilling to undergo surgery, or in the interim period until radiotherapy becomes fully effective. Acute and repeated dose toxicology, genotoxicity, carcinogenicity and reproductive toxicology studies in animals revealed no specific safety concerns for humans.
Octreotide may affect glucose regulation. Post-prandial glucose tolerance may be impaired and, in some instances, the state of persistent hyperglycaemia may be induced as octreeotide result of chronic administration. GEP endocrine tumours During the treatment of GEP endocrine tumours, there may octreotiide rare instances of sudden escape from symptomatic control by Octreotide with rapid recurrence of severe symptoms.
Subcutaneous injections Patients who will be injecting themselves must receive precise instructions from the doctor or nurse.
Octreotide 100 micrograms/1ml Solution for Injection
Table 1 Adverse drug reactions reported in clinical studies Gastrointestinal disorders Very common: After initial use, multiple-dose vials should be discarded within 14 days. Neoplastic lesions were not observed either in mice receiving daily s.
In emergency situations e. It is not known whether octreotide has an effect on human fertility. No causal relationship to octreotide is suspected for these cases. Before administration the solution has to be brought to room temperature again. Posology Acromegaly Initially 0. For the full list of excipients, see section 6. Administration of octreotide produces a fall in circulating immunoreactive insulin, which may, however, be of short duration about 2 hours.
Dose adjustments of medicinal products such as beta blockers, calcium channel blockers, or agents to control fluid and electrolyte balance, may be necessary see section 4. In cirrhotic patients with bleeding gastro-oesophageal varices, Sandostatin has been well tolerated at continuous i. In non-diabetic and type II diabetics with partially intact insulin reserves, Octreotide administration can result in post-prandial increase in glycaemia.
In very octreotire instances, acute pancreatitis has been reported within the first hours or ictreotide of Octreotie s. Clinical improvement and symptomatic benefit occur in patients who still have symptoms related to their tumours despite previous therapies, which may include surgery, hepatic artery embolization, and various chemotherapies, e.
To assess therapeutic efficacy and safety of treatment, continued patient monitoring is necessary. Packs of three, five, six, ten, twenty and fifty ampoules packed in a cardboard tray which is placed in an outer box. There is no evidence of reduced tolerability or altered dosage requirements in elderly patients treated with Sandostatin.