ELIGARD PACKAGE INSERT PDF

ELIGARD (leuprolide acetate) is indicated for the palliative due to incorrect reconstitution or administration of the product (see Monitoring and Laboratory .. Gently insert the long, white replacement plunger rod into the gray. PACKAGE LEAFLET: INFORMATION FOR THE USER. ELIGARD 45 mg powder and solvent for solution for injection. Leuprorelin acetate. Read all of this leaflet. Eligard® is a sterile polymeric matrix formulation of leuprorelin acetate for subcutaneous package insert for constitution and administration procedures.

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Drugs with a possible risk for Eigard prolongation and TdP that should be used cautiously with leuprolide include mifepristone. Once absorbed, relatively high concentrations of the drug can be found in liver, pineal, kidney, and pituitary tissues. Major Limited data indicate that QT prolongation is possible with apomorphine administration; the change in QTc interval is not significant in most patients receiving dosages within the manufacturer’s guidelines.

Withhold HCG administration in cases where the ovaries are abnormally enlarged to reduce the chance of inducing ovarian hyperstimulation syndrome OHSS. Additionally, antipsychotic-induced hyperprolactinemia results in down-regulatation of the number of pituitary GnRH receptors and may interfere with the response to leuprolide therapy; however, in contrast to most typical antipsychotics, clozapine is not eligatd associated with hyperprolactinemia.

The recommended dose is 15 mg IM as a single dose repeated every 4 weeks. Because of the potential for TdP, use of bretylium with leuprolide is contraindicated.

Eligard (leuprolide acetate) dose, indications, adverse effects, interactions from

Hold syringes vertically with syringe B on the bottom. Remove the pink cap on the bottom of the sterile needle cartridge. Send the page ” ” to a friend, relative, colleague or yourself.

HCG is then administered to induce final follicular maturation for oocyte retrieval.

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Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with leuprolide include disopyramide.

Discard any suspension not used within 2 hours of reconstitution because it does not contain preservatives. After injection, withdraw the needle from the injection site. Tamoxifen has also been reported to prolong the QT interval, usually in overdose or when used in high doses.

Because of the potential for TdP, use of dofetilide with leuprolide is contraindicated. Major Based on electrophysiology studies performed by the manufacturer, alfuzosin has a slight effect to prolong the QT interval. Androgen deprivation therapy e. Drugs such as ganirelix and cetrorelix are now more commonly used and are FDA-approved for this purpose. In patients with endometriosis, this reversible hypoestrogenic state produces symptomatic relief of the pain of endometriosis and decreases the number of endometriotic lesions.

Major Due to a possible risk for QT prolongation and torsade de pointes TdPazithromycin and leuprolide should be used together cautiously. Release the diluent by slowing pushing the plunger for 6—8 seconds, until the first stopper is at the blue line in the middle of the barrel. Recipient’s Email Separate multiple email address with a comma Please enter valid email address Recipient’s email is required.

The recommended dose is 7. Atomoxetine is also considered a drug with a possible risk of TdP. GnRH analog therapy increases the risk of reduced bone mineral density in men as well as women, and may have particular relevance for the geriatric population. Case reports indicate that QT prolongation and torsade de pointes TdP can occur during donepezil therapy. Clean the injection site with an alcohol swab prior to injection.

Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with leuprolide include tolterodine. For the treatment of central precocious puberty idiopathic or neurogenic in children. Leuprolide and FSH adjusting FSH dosage as needed are administered until sufficient follicular development is attained.

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Dligard de pointes TdP and complete atrioventricular block have been reported.

Major Avoid coadministration of inotuzumab ozogamicin with leuprolide due to the potential for additive QT prolongation and risk of torsade de pointes TdP. Insert the needle at a 90 degree angle into the gluteal area, anterior thigh, or shoulder.

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Females, geriatric patients, patients with diabetes mellitus, thyroid disease, malnutrition, alcoholism, or hepatic disease may also be at increased risk for QT prolongation.

Major Iloperidone has been associated with QT prolongation; however, torsade de pointes TdP has not been reported. Major Monitor patients for QT prolongation if coadministration of leuprolide with sunitinib is necessary. Major Pimavanserin may cause QT prolongation and should generally be avoided in patients receiving other medications known to prolong the QT interval, such as leuprolide.

Administer as a eligarrd dose subcutaneously. Like the naturally occurring hormone, leuprolide can be metabolized in the anterior pituitary and hypothalamus. Since iloperidone may prolong the QT interval, it should be avoided in combination with other agents also known to have this effect. If these drugs are administered together, obtain an electrocardiogram and electrolyte concentrations before and periodically during treatment.

Your email has been sent. Monitor hormonal and clinical parameters at month 1 to 2, with dose changes, and further as appropriate to ensure adequate suppression.

After a brief increase in serum testosterone levels, testosterone was suppressed to castrate levels from week 4 to week 48 in Several dosage regimens are possible, depending on the depot dosage used. An interruption of vandetanib therapy or dose reduction may be necessary for QT prolongation.