Am J Med. Jul;(7) Libman-Sacks endocarditis in systemic lupus erythematosus: prevalence, associations, and evolution. Moyssakis I(1). Superadded bacterial endocarditis is rare but may be difficult to distinguish from The expanding spectrum of Libman Sacks endocarditis: the role of. Background. Libman-Sacks Endocarditis (LSE) affects patients with systemic lupus erythematosus (SLE) and positive antiphospholipid.

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Clinical improvement was noted during hospital stay with completion of antibiotics, tapering of steroids, and continued anticoagulation.

For the past 2 weeks, she had intermittent fever and progressive diplopia. The patient is a 33 year-old Filipino female, diagnosed with SLE 5 years ago when she initially presented with symptoms of arthritis, alopecia, malar rash, and fever.

Transesophageal echocardiogram was done which showed echodense structures on the mitral valve consistent with vegetation or Libman Sacks endocarditis Figure 3. This case highlights the challenges in clinically differentiating infective endocarditis from Libman Sacks endocarditis in a patient with risk factors for both conditions. With the echocardiographic finding, she fulfilled 1 major criteria for infective endocarditis.

Libman–Sacks endocarditis – Wikipedia

Can’t read the image? The lesions primarily consists of accumulations of immune complexes and mononuclear cells. This page was last edited on 24 Novemberat Blood cultures on 3 sites were done; all 3 specimens did not grow any organism.

It is also known as verrucous, marantic, or non-bacterial thrombotic endocarditis. Libman—Sacks lesions rarely enodcarditis significant valve dysfunction and the lesions only rarely embolize.


Libman-Sacks endocarditis in systemic lupus erythematosus: prevalence, associations, and evolution.

It is one of the most common heart-related manifestations of lupus the most common being pericarditis.

Pharmaceutical Sciences Journals Ann Jose ankara escort. The diagnosis of Libman Sacks endocarditis becomes challenging, especially in differentiating it from infective endocarditis as both diseases may present similarly. This case report presents a female SLE patient with the above complications, confounded by the clinical setting of infective endocarditis.

Endocafditis Chagas disease Cardiomyopathy Dilated Alcoholic Hypertrophic Restrictive Loeffler endocarditis Cardiac amyloidosis Endocardial fibroelastosis Arrhythmogenic right ventricular dysplasia. She was clinically stable for the next 5 years.

A significant association was found between Libman-Sacks endocarditis and disease duration and activity, thromboses, stroke, thrombocytopenia, anticardiolipin antibodies, and antiphospholipid syndrome.

This article needs additional citations for verification. Libman Sacks endocarditis was likewise addressed with anticoagulation using low-molecular weight libman-sackd and warfarin. In the setting of SLE, antiphosphilipid syndrome was considered. Hemoglobin Hgb was 9. Unsourced material may be challenged and removed.

Libman–Sacks endocarditis

In 24 of 38 patients, mitral valve involvement was found, resulting in regurgitation in all mild in 18, moderate ebdocarditis 4, libman-scaks severe in 2whereas stenosis co-occurred with regurgitation in 9 patients mild in 6 and moderate in 3.

Cranial MRI was repeated after 3 weeks which showed normal result. She was given a regimen of penicillin G and gentamycin. Rheumatol Curr Res S We report a case libman-sacsk stroke in an SLE patient with positive anti-phospholipid antibodies and echocardiography findings of mitral valve vegetations.


June 17, ; Published date: This patient presented with symptoms of cerebrovascular disease, confirmed by cranial MRI. Hydroxychloroquine was also continued. Visit for more related articles at Rheumatology: Libman Sack lesions are associated with lupus duration, disease activity, anti-cardiolipin antibodies, and antiphospholipid syndrome [ 5 ].

She received empiric treatment for both with favourable outcome. We evaluated the prevalence and progression of Libman-Sacks endocarditis in patients with systemic lupus erythematosus and any association between this valvulopathy and their clinical and laboratory characteristics. Home Publications Conferences Register Contact.

The dilemma then was whether to treat for infective endocarditis or not. Sudden cardiac death Asystole Pulseless electrical activity Sinoatrial arrest. Motor, sensory, and deep tendon reflexes on all extremities were intact. Guidelines Upcoming Special Issues.

Libman-Sacks endocarditis in systemic lupus erythematosus: prevalence, associations, and evolution.

Angina pectoris Prinzmetal’s angina Stable angina Acute coronary syndrome Myocardial infarction Unstable angina. Prednisone and hydroxychloroquine were continued. The history of fever and embolic event may be considered as minor criteria making the diagnosis of possible infective endocarditis [ 3 ].

From Wikipedia, the free encyclopedia. D ICD – Cerebral thromboembolism remains to be endocadditis most common complication of antiphospholipid patients with Libman Sacks endocarditis [ 6 ].