Advancements in Extrusion-Spheronization. More agile techniques are improving the development of multiparticulate drug-delivery systems. Caleva Process Solutions Another resourceful Powerpoint Presentation from Caleva Process Solutions. These selection. Extrusion – to form rod shaped particles of uniform diameter. Spheronization – to round off these rods into spherical particles. Drying – to.

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Moistening the powder mixture, forming cylinder-shaped agglomerate through extrusion, breaking and rounding the extrudate to round pellets through spheronization, and drying the finished product. Cookies allow us to give you the best browsing experience and help us to understand how you use our site. This dough then pressed through an extruder.

Extrusion & Spheronization Pharmaceutical Technology

Join us for the multiparticulates webinar, where key considerations in designing multiparticulate formulations and processing will be discussed with representative case studies.

Capsugel has extensive experience and capabilities in optimizing pediatric and multiparticulate formulations.

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The Extrusion Spheronization Processs

Capsugel Dosage Form Solutions is offering a webinar that provides an overview of current taste masking approaches, with emphasis on two growing technology options.

In the pharmaceutical industry, pellets of medium particle sizes from to 2, micrometers are used for spheronizzation applications. The spheres may undergo additional processing steps to apply functional or cosmetic coatings using fluid bed processing with a Wurster insert. The dry, mixed, powdery active substances are kneaded into a dough with a liquid. Capsugel spheronizatioj a drug delivery technology to provide oral delivery with full enteric protection and rapid release in the upper gastrointestinal GI tract without the use of coatings.


Capsugel is well versed in using drug layering and modified-release coat layering to achieve a range of dissolution profiles in multiparticulate format. The wet mass is added into an LCI Multigranulator MG 55 where it is forced through a specific screen to form cylindrical extrudates using either dome, radial or axial extrusion for process optimization.

Our Exhrusion are a popular finished dosage form presentation and offers the benefits of multiparticulates while using established tableting technology. By continuing to use this website, you agree that we may store and access cookies on your device. Please read our updated Cookies Policy for information about which cookies we use and the information we collect.

Agglomeration through extrusion and spheronization is one of the oldest techniques for spheronizaton pellets. For technical reasons, the resulting pellets are larger than spheronizattion. For many pharmaceutical applications, extruded pellets are achieved in suitable quality if a sufficient portion of microcrystalline cellulose is added. The technology chosen is dependent upon multiple active ingredient and formulation criteria, e.

It is useful for making dense granules for controlled-release solid oral dosage forms with a minimum amount of excipients, as well as multiparticulates used for immediate, modified, or sustained-release. The coated spheres may be used for encapsulation, compression, or direct packaging into sachets or pouches for dosing. Primary packaging in either vials or sachets and secondary packaging services are also available. Spheronizatikn can disable cookies but parts of our website may not work.


In other industries, the size of the pellets can be several centimeters. Application of Multiparticulate Technologies for Drug Delivery.

The ratio of liquid to solid material together with the size of the extruder holes significantly determines the quality of the extrudates. The process consists of four process steps: Capsugel has extensive experience in designing, formulating and scaling mulitparticulate dosage forms at feasibility, pilot and commercial scales.

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Extrusion / Spheronization

The wet extrudate is added to an LCI Marumerizer QJT spheronizer equipped with anr high speed spinning plate which forms uniform spheres from the extrudate “rope”. By Product Development Site.

Just the way you need it. Read more about it here! The diameter of the openings in the extrusion plate or extrusion basket determines the strength of the elongated extrusion threads that result.

By visiting our website or using services provided by Lonza, you are accepting the practices described in the Privacy Policy. The process consists of five operations. The final drying ensures the pellet hardness. Even if the ball-shaped extrudate is imperfect, the evenness of the surface still creates good conditions for subsequent coating.

The resultant spheres are dried in a fluid bed dryer and particle size is selected by sieve cuts. Exttusion applications include delayed release, extended release, pulsatile release, and fixed dose combinations.

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