Compare Anti-Glucose Transporter GLUT3 antibody ab from Abcam on Be the first to write a review! Rabbit polyclonal to Glucose Transporter GLUT3. C5 and T4 cells showed the highest rate of GLUT-3 expression. These cells were ORL J Otorhinolaryngol Relat Spec. ;– glucose transporter 3 (GLUT3)2 is the major GLUT subtype in .. platelets without additional Ca2 at 20 °C in a F fluorescence spec-.

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Ductulogenic capacity and solid mass formation were evaluated as previously described [ 2830 ]. Kinase-specific phosphorylation of the estrogen glht3 changes receptor interactions with ligand, deoxyribonucleic acid, and coregulators associated with alterations in estrogen and tamoxifen activity.

It has been also observed that more advanced tumor stages are associated with more increased glucose uptake. However, when this cell line is subjected to carcinogenic exposure i.

Functional properties and genomics of glucose transporters. Cells from each treatment group were plated in eight well chambers pre-coated with 0. Neeman M, Degani H. Am J Clin Pathol. Lieberman M, Marks AD. There is growing evidence that hypoxia inducible factor HIF system plays a critical role in the gain of GLUT expression characteristics.

Undoubtedly, besides Glut1, 3 and 12, other isoforms need to be analyzed using our model system in further studies for better understanding of estrogen induced tumor biology and defining novel molecular targets. A prospective study of endogenous estrogens and breast cancer in postmenopausal women.


Epithelial to mesenchymal transition in human breast epithelial cells transformed by 17beta-estradiol. Airley RE, Mobasheri A. flut3

GLUT – The OpenGL Utility Toolkit

For example, Suganuma et al. The epec final edited version of this article is available at Clin Transl Oncol. Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression. Modulation of glucose transporter1 Glut1 expression levels alters Mouse mammary tumor cell growth in vitro and in vivo.

Taken together, Glut1, 3, and 12 seem to be relevant to estrogen-induced mammary carcinogenesis and malignant transformation. J Mammary Gland Biol Neopl. For example, Glut-1 is extensively expressed in brain tissues under the normal gljt3 [ 10 ].

For example, Glut1 is a main isoform on erythrocytes and brain cell membranes, whereas Glut5 of glu3t membranes are used mainly for fructose transport into skeletal muscle cells [ 12 ]. EGFR signaling pathway in breast cancers: Microenvironmental regulation of estrogen signals in breast cancer.

On the other hand, quite a few data have been published about the role of estrogens on Glut3 expression in tumoral cell lines. The transformed cells E2, C5, T4 lost their ductulogenic capacity in collagen matrix glu3t showed mass formation gkut3 column.


Therefore, estrogenic dependence is obvious in almost all steps of mammary carcinogenesis. Schematic presentation of the previous experimental protocol and genomic characteristics of the cell lines used are summarized in Fig. Similar results have been observed in normal and malignant breast tissues with respect to Glut12 expression.

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Mean colony number in C5 group was statistically higher than T4 Student t test. J Steroid Biochem Mol Biol. Direct action of estrogen on sequence of progression of human preneoplastic breast disease. Colony formation of represented cells in Agar methocel right column.

A family of glucose transporters GLUTs facilitates the movement of glucose across the plasma membranes in a tissue-specific manner, dependent on concentration gradient.

Author information Copyright and License information Disclaimer. Glut-1 antibodies induce growth arrest and apoptosis in human cancer cell lines. High correlations between primary tumours and loco-regional metastatic lymph nodes in non-small-cell lung cancer with respect to glucose transporter type 1-mediated 2-deoxy-2Ffluoro-d-glucose uptake. Regulation of glut1 mRNA by Hypoxia- inducible factor Solute carrier family 2 facilitated glucose transportermember 1.