Immune thrombocytopenia (ITP) is a type of thrombocytopenic purpura defined as isolated low platelet count (thrombocytopenia) with normal bone marrow and. Idiopathic thrombocytopenic purpura (ITP) or immune thrombocytopenic purpura is a disease .. Purwanto I. Purpura trombositopenia idiopatik. In: Sudoyo AW. Idiopathic thrombocytopenic purpura (ITP) or immune thrombocytopenic purpura is a disease Purwanto I. Purpura trombositopenia idiopatik.
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The major causes of accelerated platelet consumption include immune thrombocytopenia, decreased bone marrow production, and increased splenic sequestration. ITP is a disorder idiooatik affects the overall number of blood platelets rather than their function.
History of presenting illness revealed that patient noticed bleeding from his gums in lower front teeth region approximately 2 weeks before reporting to purupra and patient was having purpuric spots on body legs, hands, and neck since past 2 months. Allergic contact dermatitis Mantoux test. The epidemiology of immune thrombocytopenic purpura.
From traditional medicines to modern drugs. Support Center Support Center. Management of ITP is based on platelet count and severity of bleeding. Increased antiplatelet T helper lymphocyte reactivity in patients with autoimmune thrombocytopenia.
Review provided by VeriMed Healthcare Network. In mild cases, only careful observation may be required but very low counts or significant bleeding trombositipenia prompt treatment with corticosteroidsintravenous immunoglobulinanti-D immunoglobulinor immunosuppressive medications.
In adults, particularly those living in areas with a high idiopatlk of Helicobacter pylori which normally inhabits the stomach wall and has been associated with peptic ulcersidentification and treatment of this infection has been shown to improve platelet counts in a third of patients. The decision to treat ITP is based on the platelet count, degree of bleeding, and patient’s lifestyle. For patient with active H.
IDIOPATIK TROMBOSITOPENIA PURPURA PDF
Hypo- coagulability Thrombocytopenia Thrombocytopenic purpura: Older patients have more severe and rare bleeding manifestations, such as GI bleeding and possibly intracranial hemorrhage secondary to co-morbidities such as hypertension. Thrombocytopenia caused by immunologic platelet destruction. Patient started treatment 7 years back and was on tablet isosorbide dinitrate 10 mg, tablet atenelol 25 mg, tablet envas 5 mg and patient had discontinued aspirin 6 months back.
Pediatr Rev ; Idiopathic thrombocytopenic purpura ITP is the condition of having a prpura platelet count thrombocytopenia of no known cause idiopathic. The diagnosis of ITP also requires a medical history anamnesisphysical examination, platelet count, and examination of a peripheral blood smear.
Immune thrombocytopenic purpura
Refractory ITP not responsive to conventional treatment may require splenectomythe surgical removal of the spleen. Therefore, ITP is a significant cause of fetal and neonatal immune thrombocytopenia.
On complete blood cell count, isolated thrombocytopenia is the hallmark of ITP. The pathophysiology of ITP revisited: It is recommended that neonates be followed with serial platelet counts for the first few days after birth. There is marked variability in the clinical presentation of ITP.
Nevertheless, in the case of an ITP patient already scheduled for surgery who trombositopeni a dangerously low platelet count and has experienced a poor response to other treatments, IVIg can rapidly increase platelet counts, and can also help reduce the risk of major bleeding by transiently increasing platelet counts.
Thrombopoietin receptor agonists are pharmaceutical agents that stimulate platelet production in the bone marrow. N Engl J Med ; Care, Recommendations, and Protecting Practitioners. All the petechial lesions were completely resolved over the neck, arm, and forearms. Retrieved from ” https: A report of 66 cases. Some children may need treatment. Signs of chronic disease, infection, wasting, or poor nutrition indicate that the patient has another illness.
Cellular immune mechanisms in autoimmune thrombocytopenic purpura: Management of ITP is based on platelet count and severity of bleeding. Intraoral examination revealed bleeding from gingiva in lower anterior region, which was inflamed, reddish, tender on palpation, soft in consistency [ Figure 3 ].
Recent research now indicates that impaired production of the glycoprotein hormone thrombopoietinwhich is the stimulant for platelet production, may be a contributing factor to the reduction in circulating platelets. Transfusion-associated graft versus host disease.
Graves’ disease Myasthenia gravis Pernicious anemia. Secondary causes could be leukemia, medications e. The clinical signs of ITP are purpura, ecchymosis, petechiae and gastrointestinal tract bleeding, gingival bleeding, epistaxis, and urinary tract bleeding. Conclusion The initial treatment of ITP includes: After several weeks of prednisone therapy, the dose is gradually reduced.
The size and appearance of the platelets may be abnormal. There is increasing use of immunosuppressants such as mycophenolate mofetil and azathioprine because of their effectiveness.