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The 5′-flanking sequence of human interferon-beta 1 gene is responsible for viral induction of transcription.

Changes of chromatin conformation around mouse interferon-beta gene associated with induction of interferon synthesis. Short and long range activation by the SV40 enhancer. The human beta-interferon gene enhancer is under negative control. Structure of a chromosomal gene for human interferon beta. IRF-1 may also be involved in silencing the function of the SV40 enhancer juxtaposed to the regulatory elements in uninduced cells.

Interaction of positive and negative regulatory proteins in the galactose regulon of yeast. A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes.

410 transcription of a human alpha-interferon gene introduced into mouse L cells. Heat shock factor is regulated differently in yeast and HeLa cells.


Human embryonic lung cells HEL-R66 are of monkey origin. Abstract Transcription of the human interferon-beta IFN-beta gene is induced by a variety of agents such as viruses, dsRNA and some cytokines. Establishment of a permanent cell line HEL-R66 from human embryonic lung cells with high susceptibility to viruses. Associated Data Supplementary Materials.

Transcription of the human interferon-beta IFN-beta gene is induced by a variety of agents such as viruses, dsRNA and some cytokines. Regulation of gene expression by interferons: Human beta-interferon gene expression is regulated by an inducible enhancer element. Open in a separate window.

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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian 46610. Intracytoplasmic phosphorylation sites of Tac antigen p55 are not essential for the conformation, function, and regulation of the human interleukin 2 receptor. Please review our privacy policy.

This article has been cited by other articles in PMC. In this study, we describe a nuclear factor, termed interferon regulatory factor-1 IRF-1that is involved in the transcription of IFN-beta and possibly other genes. Our data suggest that IRF-1 participates in the transient formation of an induction-specific complex es with the regulatory elements. Reversible silencing of enhancers by sequences derived from the human IFN-alpha promoter. Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor.


Support Center Support Center. High efficiency DNA-mediated transformation of primate cells.

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Delimitation and properties of DNA sequences required for the regulated expression of human interferon-beta gene. Identification of two distinct regulatory regions adjacent to the human beta-interferon gene. Images in this article Image on p. Regulation of cytokine gene expression.

Biochemistry of interferons and their actions.

BK viral enhancer element and a human cellular homolog. Author information Copyright and License information Disclaimer. A nucleotide promoter segment from an IFN-alpha gene renders an unrelated promoter inducible by virus.

Affinity purification of sequence-specific DNA binding proteins. National Center for Biotechnology InformationU. Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.