ergogenic aid for increase sports performance seems to have potential () L-Arginine as a Potential Ergogenic Aidin Healthy Subjects. L-arginine as a potential ergogenic aid in healthy subjects. Sports Medicine, 41(3 ), doi/ Bahra, M., Kapil, V. Dietary nitrates and L-Arginine have been increasingly recognized to play a promising Recently, nitric oxide (NO) has emerged as a promising ergogenic aid by .. factor for exercise tolerance in healthy subjects, suggesting the potential of.

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The most significant controversy is concerned with the use of pharmaceutical NO 3. The primary aim of ergogenic aids consumption is to improve aa performance, muscle strength and delay the onset of fatigue [ 2 ]. However, the supplement was mixed with several other compounds including citrulline, vitamin E, and alpha lipoic acid; therefore, the authors could not conclude that the increase in anaerobic threshold was solely due to L-arg.

Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training. Ergogenjc nitrate supplementation lowers blood pressure in humans role for nitrite-derived NO. In accordance with this notion, no difference in strength and weight lifting performance was found between creatine and placebo groups during an 8-wk resistance training program, when the training volume was constant between groups High-intensity suhjects human muscle performance enhanced by a metabolic intervention.

There is a strong ergogeinc between the change in plasma NO 2 levels and a change in performance. The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash. Essential amino acids stimulate muscle protein anabolism in healthy older adults regardless of the presence of non-essential amino acids. The results suggest that arginine and ornithine taken in conjunction with a high intensity strength training program can significantly increase muscle strength and lean body mass Journal of the International Society of Sports Nutrition4 16.

Hea,thy short summary is given below.

L-Arginine as a potential ergogenic aid in healthy subjects.

Many athletes ingest creatine over long periods of time, and not only in connection with special events 57 Within the cardiovascular system, basal endothelial NO release plays a critical role in sustaining cardiovascular health, by exerting vasodilator, anti-platelet, anti-proliferative and anti-leucocyte phenotype [ 9 ].


Still focusing at cellular level, NO seems to potentiate the potentlal of satellite cells, halthy in skeletal muscle fascicles, exerting a positive stimulus to muscular hypertrophy.

Nitric Oxide NO is an endogenous free radical and a potent vasodilator in the human body. In what concerns chronic L-Arginine supplementation, it has been linked to a positive influence in pptential and increment in VO2max, and exercise capacity, likely due to the rise in NO production, lessening both plasma lactate concentration and heart rate [ 28 ].

The literature appears consistent in showing that days or up to 15 hsalthy of supplementation can subjwcts indices of performance during high-intensity constant work-rate exercise and maximal incremental exercise. Nitrate and nitrite are the main substrates to produce NO via the NOS-independent pathway, which seems to complement the endogenous NO production, especially during ischaemia and acidosis, in which oxygen availability is low and the NO synthases poorly operate [ 22 ].

In patients with cardiovascular disease, intravenous and oral arginine administration have been shown to support endothelial function by enhancing vasodilation and reducing monocyte adhesion 10 — In turn, inorganic NO 3 -in doses achievable through diet, seems to improve metabolic and mechanical efficiency during exercise in healthy subjects, due to several mechanisms involving mitochondria, muscle and vasculature [ 9 ]. The effect on these organ systems also needs to be included in long-term, randomized, controlled studies.

Despite such fears, NaNO 3 supplements, if taken safely with dietary nitrate, do not cause any significant protein eryogenic over an acute dosage period.

Creatine supplementation patterns and perceived effects in select division I l-aginine athletes. Nevertheless, taken together, it is suggested that creatine supplementation is of benefit to exercise lasting 30 s or less. Arginine supplementation has been shown to improve NOdependent endothelial relaxation in patients with major cardiovascular risk factors hypercholesterolemia, smoking, hypertension, diabetes, obesity, insulin resistance, aging and many ordinary cardiovascular disorders [ ergovenic ].


Localization of NOS both in mitochondria and along contractile fibers accentuates the role of NO in respiratory and contractile functions of skeletal muscles, which also takes part in muscle repair and helps tolerate heavy exercise [ 29 ].

Concerning 6g-L-Arginine supplementation in strength performance, there is good evidence supporting strength and power progresses, improving nutrient uptake and ATP utilization, but muscle growth uplift is still under controversy [ 26 ].

Journal of Strength and Conditioning Research25 3 However, whether NO-cGMP-induced mitochondrial biogenesis is manifested in human skeletal muscle in vivo following dietary nitrate intervention still remains to be determined [ 22 ]. The mixed supplementation casts doubt on the validity of these conclusions.

Of minor concern is that subjects who supplemented with BRJ also reported minor side effects such as Beeturia and red stools Bailey et al. Historically, NO has been widely used in clinical settings because of its vasodilatory effects.

L-Arginine as a potential ergogenic aid in healthy subjects.

Email alerts New issue alert. To sum up, both L-Arginine and exercise increase NO production by skeletal muscle [ 28 ]. Acute exercise increases nitric oxide synthase activity helathy skeletal muscle. It is also important to note that a few studies had experimented with NO 3 supplements that had been potenrial with other compounds. NO also reduces glycolysis in hepatocytes by decreasing levels of some key enzymes, like glucokinase and glyceraldehyde dehydrogenase [ 20 ].

Effect of creatine loading on endurance capacity and sprint power in cyclists. Potential ergogenic effects of l-arginine fall into 2 general categories: Arginine as a secretagogue.

Curiously, NO modulates the mechanical behaviour of skeletal muscle cells through a decrease in calpain-mediated cytoskeletal proteolysis [ 32 ]. Furthermore, mitochondrial function ergogeni essential for skeletal muscle metabolism, producing adenosine triphosphate ATP synthesis from different sources carbohydrates, lipids, proteins… [ 31 ].

Arginine supplementation in healthy and patient populations.